The Papanicolaou's solution Orange G (OG-6) 4L from Medil is for cytological cancer diagnosis. The cytological staining technique developed by Papanicolaou remains the standard method for cancer and hormone cycle diagnosis. The effect of the orange staining solution is significant in smears with keratinized cells under acidic pH conditions, when the apparent orangeophilic cytoplasmic stain is recognizable and may indicate the presence of hyperkeratosis, HPV infection, or carcinoma cells. The Papanicolaou's solution Orange G (OG-6) 4L from Medil gives an intense yellow-orange staining result with mature and keratinized squamous cells. Papanicolaou's solution 2b, Orange II solution gives an intense reddish result with mature and keratinized squamous cells. One 500ml bottle is sufficient for 1500-2000 stains. The Papanicolaou's solution Orange G (OG-6) 4L from Medil is an IVD approved product and CE certified, thus it can be used for clinical diagnostic purposes.